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History and origin of the HIV-1 subtype C epidemic in South Africa and the greater southern African region

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dc.contributor.author Wilkinson, Eduan
dc.contributor.author Engelbrecht, Susan
dc.contributor.author de Oliveira2, Tulio
dc.date.accessioned 2018-02-16T09:14:05Z
dc.date.available 2018-02-16T09:14:05Z
dc.date.copyright 2015
dc.date.created 2017
dc.date.issued 2015
dc.identifier.citation Wilkinson, E. et al. History and origin of the HIV-1 subtype C epidemic in South Africa and the greater southern African region. Sci. Rep. 5, 16897; doi: 10.1038/srep16897 (2015). en_US
dc.identifier.uri http://hdl.handle.net/10907/1611
dc.description.abstract HIV has spread at an alarming rate in South Africa, making it the country with the highest number of HIV infections. Several studies have investigated the histories of HIV-1 subtype C epidemics but none have done so in the context of social and political transformation in southern Africa. There is a need to understand how these processes affects epidemics, as socio-political transformation is a common and on-going process in Africa. Here, we genotyped strains from the start of the epidemic and applied phylodynamic techniques to determine the history of the southern Africa and South African epidemic from longitudinal sampled data. The southern African epidemic’s estimated dates of origin was placed around 1960 (95% HPD 1956–64), while dynamic reconstruction revealed strong growth during the 1970s and 80s. The South African epidemic has a similar origin, caused by multiple introductions from neighbouring countries, and grew exponentially during the 1980s and 90s, coinciding with socio-political changes in South Africa. These findings provide an indication as to when the epidemic started and how it has grown, while the inclusion of sequence data from the start of the epidemic provided better estimates. The epidemic have stabilized in recent years with the expansion of antiretroviral therapy. en_US
dc.description.statementofresponsibility This work is licensed under a Creative Commons Attribution 4.0 International License. en_US
dc.format.extent 12 p. en_US
dc.format.medium pdf en_US
dc.language.iso en en_US
dc.publisher DOI: 10.1038/srep16897 en_US
dc.relation.requires Adobe Acrobat Reader en_US
dc.relation.uri doi: 10.1038/srep16897 en_US
dc.rights.uri www.nature.com en_US
dc.subject origin of the HIV-1 subtype C epidemic en_US
dc.subject South Africa en_US
dc.subject greater southern African region en_US
dc.title History and origin of the HIV-1 subtype C epidemic in South Africa and the greater southern African region en_US
dc.type Article en_US


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