Abstract:
Although most of what is known about the biology and function of arachidonic acid metabolites comes from the
study of mammalian biology, these compounds can also be produced by lower eukaryotes, including yeasts and
other fungi. It is also in this group of organisms that the least is known about the metabolic pathways leading to
the production of these compounds as well as the functions of these compounds in the biology of fungi and
yeasts. This review will deal with the discovery of oxylipins from polyunsaturated fatty acids, and more specifically
the arachidonic acid derived eicosanoids, such as 3-hydroxy eicosatetraenoic acid, prostaglandin F2α and
prostaglandin E2, in yeasts starting in the early 1990s. This review will also focus on what is known about the
metabolic pathways and/or proteins involved in the production of these compounds in pathogenic yeasts. The
possible roles of these compounds in the biology, including the pathology, of these organisms will be discussed.
