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Characterisation of mucosal tissue in the foreskin after voluntary medical male circumcision

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dc.contributor.advisor Gray, Clive M
dc.contributor.advisor Olivier, Abraham Jacobus
dc.contributor.author Harryparsad, Rushil
dc.date.accessioned 2016-07-25T12:12:04Z
dc.date.available 2016-07-25T12:12:04Z
dc.date.copyright 2016
dc.date.created 2016
dc.date.issued 2016-03
dc.date.submitted 2016-01-13
dc.identifier.uri http://hdl.handle.net/10907/628
dc.description.abstract Background: Medical Male Circumcision (MMC) reduces the risk of HIV-1 acquisition by up to 60% as shown in a number of randomized controlled trials in Uganda, Kenya and South Africa. MMC has also been shown to reduce the prevalence of other sexually transmitted infections (STIs) like Herpes Simplex Virus (HSV) -2 and Human Papillomavirus (HPV) by 25% and 35% respectively. Asymptomatic STIs may elevate the risk of HIV-1 acquisition by recruiting HIV-1 target cells to the foreskin. The higher permeability of the inner foreskin may play a role in HIV-1 acquisition as well as the number of target cells present in the foreskin. The more inflamed inner foreskin may be increasing the risk of a productive HIV-1 infection. The aims of this dissertation was to a) examine the levels of keratinisation in the inner and outer foreskins after MMC; b) investigate the number of Langerhans, Ki67+ and CD4+ T cells in the inner and outer foreskin and c) identify the impact of asymptomatic STIs on the numbers and proliferative capacity of foreskin-resident Langerhans and CD4+ T cells. en_US
dc.description.sponsorship National Research Foundation en_US
dc.format.extent 148 p. en_US
dc.format.medium pdf en_US
dc.language.iso en en_US
dc.publisher University of Cape Town en_US
dc.relation.requires Adobe Acrobat Reader en_US
dc.relation.uri http://hdl.handle.net/11427/20563 en_US
dc.rights University of Cape Town en_US
dc.subject Foreskin en_US
dc.subject Circumcision en_US
dc.subject Adolescents en_US
dc.subject Langerhan's cells en_US
dc.subject Keratinisation en_US
dc.subject HIV and STI's en_US
dc.title Characterisation of mucosal tissue in the foreskin after voluntary medical male circumcision en_US
dc.type Thesis en_US
dc.rights.holder University of Cape Town en_US
dc.contributor.orcid 0000-0003-3263-7674 en_US


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