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Clinical diagnostic utility of IP-10 and LAM Antigen levels for the diagnosis of tuberculous pleural effusions in a high burden setting

Dheda, Keertan; Van-Zyl Smit, Richard N.; Sechi, Leonardo A.; Badri, Motasim; Meldau, Richard; Symons, Gregory; Khalfey, Hoosein; Carr, Igshaan; Maredza, Alice; Dawson, Rodney; Wainright, Helen; Whitelaw, Andrew; Bateman, Eric D.; Zumla, Alimuddin (PLoS ONE, 2009)

Current tools for the diagnosis of tuberculosis pleural effusions are sub-optimal. Data about the value of new diagnostic technologies are limited, particularly, in high burden settings. Preliminary case control studies ...
Marked independent relationship between circulating interleukin-6 concentrations and endothelial activation in rheumatoid arthritis

Dessein, Patrick H.; Solomon, Ahmed; Woodiwiss, Angela J.; Norton, Gavin R.; Tsang, Linda; Gonzalez-Gay, Miguel A. (2013)

We examined the potential impact of conventional compared with nonconventional cardiovascular risk factors including interleukin-6 levels on endothelial activation in RA. Circulating soluble E-selectin, vascular cell ...
Adiponectin and Atherosclerosis in Rheumatoid Arthritis

Dessein, Patrick H.; Tsang, Linda; Solomon, Ahmed; Woodiwiss, Angela J.; Millen, Aletta M. E.; Norton, Gavin R. (Hindawi Publishing Corporation Mediators of Inflammation, 2014)

In the present study, we examined the potential impact of adiponectin on carotid ultrasound determined atherosclerosis in 210 (119 black and 91 white) RA patients in mixed regression models. Total adiponectin concentrations ...
On the stochastic 3D navier-stokes-α model of fluids turbulence

Deugoue, Gabriel; Sango, Mamadou (Hindawi Publishing Corporation, 2009)

We investigate the stochastic 3D Navier-Stokes-α model which arises in the modelling of turbulent flows of fluids. Our model contains nonlinear forcing terms which do not satisfy the Lipschitz conditions. The adequate ...
In vitro cytotoxicity of crude alkaloidal extracts of South African Menispermaceae against three cancer cell lines

De Wet, H.; Fouche, G.; Van Heerden, F. R. (African Journal of Biotechnology, 2009)

The cytotoxicity of crude alkaloid extracts obtained from the leaves and rhizomes of all the South African members of the family Menispermaceae (seven genera and 13 species) was tested against MCF7 (breast), UACC62 ...
In black South Africans from rural and urban communities, the 4G/5G PAI-1 polymorphism influences PAI-1 activity, but not plasma clot lysis time

de Lange, Zelda; Rijken, Dingeman C.; Hoekstra, Tiny; Conradie, Karin R.; Jerling, Johann C.; Pieters, Marlien (PLoS ONE, 2013)

Data on genetic and environmental factors influencing PAI-1 levels and their consequent effect on clot lysis in black African populations are limited. We identified polymorphisms in the promoter area of the PAI-1 gene and ...
Assessment of potential anti-cancer stem cell activity of marine algal compounds using an in vitro mammosphere assay

de la Mare, Jo-Anne; Sterrenberg, Jason N.; Sukhthankar, Mugdha G.; Chiwakata, Maynard T.; Beukes, Denzil R.; Blatch, Gregory L.; Edkins, Adrienne L. (Cancer Cell International, 2013)

The cancer stem cell (CSC) theory proposes that tumours arise from and are sustained by a subpopulation of cells with both cancer and stem cell properties. One of the key hallmarks of CSCs is the ability to grow ...
Black holes, cosmological solutions, future singularities, and their thermodynamical properties in modified gravity theories

de la Cruz-Dombriz, Alvaro; S´aez-G´omez, Diego (Entropy, 2012)

Along this review, we focus on the study of several properties of modified gravity theories, in particular on black-hole solutions and its comparison with those solutions in General Relativity, and on Friedmann–Lemaˆıt ...
The changing role of non-state actors’ relations in post apartheid South Africa: a case study of two Eastern Cape non-governmental organisations (NGOs)

Chirowamhangu, Raymond, Farai (University of Fort Hare, 2016)

This study focused on the changing role of non-state actors’ political relations in post-apartheid South Africa. During the apartheid period, NGOs were considered to be pushing a people-centered agenda, but the transition ...
Food ingredient extracts of cyclopia subternata (Honeybush): variation in phenolic composition and antioxidant capacity

de Beer, Dalene; Schulze, Alexandra E.; Joubert, Elizabeth; de Villiers, André; Malherbe, Christiaan J.; Stander, Maria A. (Molecules, 2012)

Cyclopia subternata plants are traditionally used for the production of the South African herbal tea, honeybush, and recently as aqueous extracts for the food industry. A C. subternata aqueous extract and mangiferin (a ...
Relationships between functional herd life and conformation traits in the South African Jersey breed

du Toit, J.; van Wyk, J.B.; Maiwashe, A. (South African Journal of Animal Science, 2012)

The genetic relationship between conformation traits and functional herd life of the South African Jersey population was investigated. Data on conformation traits (n = 46 238) and functional herd life (n = 90 530) on ...
Investigating the role of gene-gene interactions in TB susceptibility

Daya, Michelle; van der Merwe, Lize; van Helden, Paul D.; Möller, Marlo; Hoal, Eileen G. (PLoS ONE, 2015)

Tuberculosis (TB) is the second leading cause of mortality from infectious disease worldwide. One of the factors involved in developing disease is the genetics of the host, yet the field of TB susceptibility genetics has ...
cis-Bis(benzyldiphenylphosphane-jP)- dichloridoplatinum(II) dichloromethane sesquisolvate

Davis, Wade L.; Meijboom, Reinout (2011)

The asymmetric unit of the title compound, [PtCl2(C19H17P)2]2 3CH2Cl2, contains two complex molecules and three dichloromethane solvent molecules, two of which are disordered over various positions. The PtII complexes reveal ...
(Acetylacetonato-j2O,O0)carbonyl- {dicyclohexyl[4-(dimethylamino)phenyl]- phosphane-jP}rhodium(I)

Davis, Wade L.; Meijboom, Reinout (2011)

The title compound, [Rh(C5H7O2)(C20H32NP)(CO)], features an acetylacetonate-chelated RhI cation coordinated by one P [Rh—P = 2.2525 (7) A ° ], one carbonyl C [Rh—C = 1.792 (3) A ° ] and two O [Rh—O = 2.0582 (17) and ...
Isolation of bis(1,4-diphenyl-1,4-bis(2-pyridyl)-2,3-diaza- 1,3-butadiene)disilver with bridging (N-N) dinucleating subunits: formation of a 6-membered chelate ring

Datta, Amitabha; Revaprasadu, Neerish (2010)

A novel Ag(I) dinuclear complex {[(C6H5)(C5H4 N)-C=N-N=C-(C5H4 N)(C6H5)]Ag}2 .ClO4 (ClO4) (1/2CH3CN) (1) that was derived under mild conditions, during the course of combination of AgClO4 with a polymorphic azine ligand, ...
Extinction risk and diversification are linked in a plant biodiversity hotspot

Davies, T. Jonathan; Smith, Gideon F.; Bellstedt, Dirk U.; Boatwright, James S.; Bytebier, Benny; Cowling, Richard M.; Forest, Fe´ lix; Harmon, Luke J.; Muasya, Muthama A.; Schrire, Brian D.; Steenkamp, Yolande; van der Bank, Michelle; Savolainen, Vincent (2011)

It is widely recognized that we are entering an extinction event on a scale approaching the mass extinctions seen in the fossil record. Present-day rates of extinction are estimated to be several orders of magnitude greater ...
The M3 Muscarinic Receptor Is Required for Optimal Adaptive Immunity to Helminth and Bacterial Infection

Darby, Matthew; Schnoeller, Corinna; Vira, Alykhan; Culley, Fiona; Bobat, Saeeda; Logan, Erin; Kirstein, Frank; Wess, Jürgen; Cunningham, Adam F.; Brombacher, Frank; Selkirk, Murray E.; Horsnell, William G. C. (PLOS Pathogens, 2014)

Innate immunity is regulated by cholinergic signalling through nicotinic acetylcholine receptors. We show here that signalling through the M3muscarinic acetylcholine receptor (M3R) plays an important role in adaptive ...
The diameter of almost eulerian digraphs

Dankelmann, Peter; Volkmann, L. (The electronic journal of combinatorics, 2010)

Soares [J. Graph Theory 1992] showed that the well known upper bound 3 +1 n+ O(1) on the diameter of undirected graphs of order n and minimum degree also holds for digraphs, provided they are eulerian. In this paper ...
An Angiotensin I-Converting Enzyme Mutation (Y465D) Causes a Dramatic Increase in Blood ACE via Accelerated ACE Shedding

Danilov, Sergei M.; Gordon, Kerry; Nesterovitch, Andrew B.; Lu¨ nsdorf, Heinrich; Chen, Zhenlong; Castellon, Maricela; Popova, Isolda A.; Kalinin, Sergey; Mendonca, Emma; Petukhov, Pavel A.; Schwartz, David E.; Minshall, Richard D.; Sturrock, Edward D. (2011)

Angiotensin I-converting enzyme (ACE) metabolizes a range of peptidic substrates and plays a key role in blood pressure regulation and vascular remodeling. Thus, elevated ACE levels may be associated with an increased ...
NRF awards 2017 video

National Research Foundation (2017-09)

The annual NRF Awards recognise and celebrate South African research excellence. The awards presented to researchers are in two categories, the ratings linked awards and special recognition awards. The rating linked awards ...